Aim.To compare urodynamic effects of beta-blockers with different selectivity (propranolol, metoprolol, nebivolol) in patients with arterial hypertension (HT) and concomitant benign prostatic hyperplasia (BPH).Material and methods.32 patients (aged 67,5 y.o.
in average) with HT of 1-2 stages were involved in the study.All patients had BPH (prostate volume >40 sm3 , increase luce chandelier of residual urine volume) with moderate or severe low urinary tract symptoms (IPSS 8-25) and reduction of maximum urine flow rate to 5-13 ml/s.The urodynamic effect of beta-blockers was estimated by changes of urination frequency and uroflowmetry indices after single taking and 14-day therapy.Results.Propranolol and metoprolol led here to aggravation of urination disorders.
Nebivolol resulted in soft urodilating and urostimulating effects.It led to urination improvement and reduced a risk of urodynamic disorders.Conclusion.Urodynamic effects of cardiovascular drugs should be considered by practitioners especially in treatment of elderly patients.